Protein-coding gene in the species Homo sapiens
| CELA2A |
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| Identifiers |
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| Aliases | CELA2A, ELA2A, PE-1, chymotrypsin like elastase family member 2A, chymotrypsin like elastase 2A, AOMS4 |
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| External IDs | OMIM: 609443; MGI: 95316; HomoloGene: 40598; GeneCards: CELA2A; OMA:CELA2A - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 1 (human)[1] |
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| | Band | 1p36.21 | Start | 15,456,728 bp[1] |
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| End | 15,472,091 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 4 (mouse)[2] |
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| | Band | 4 D3|4 74.75 cM | Start | 141,542,273 bp[2] |
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| End | 141,553,471 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - body of pancreas
- islet of Langerhans
- duodenum
- testicle
- right adrenal gland
- left adrenal gland
- left adrenal cortex
- right adrenal cortex
- ectocervix
- fundus
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| | Top expressed in | - pyloric antrum
- islet of Langerhans
- pancreatic acinus
- duodenum
- sexually immature organism
- blastocyst
- embryo
- embryo
- morula
- esophagus
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| | More reference expression data |
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| BioGPS |  | | More reference expression data |
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| Gene ontology |
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| Molecular function | - serine hydrolase activity
- peptidase activity
- serine-type peptidase activity
- hydrolase activity
- endopeptidase activity
- serine-type endopeptidase activity
| | Cellular component | - keratohyalin granule
- extracellular region
- extracellular space
- cytosol
| | Biological process | - proteolysis
- cornification
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 1: 15.46 – 15.47 Mb | Chr 4: 141.54 – 141.55 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Chymotrypsin-like elastase family member 2A is an enzyme that in humans is encoded by the CELA2A gene.[5][6][7]
Function
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2A is secreted from the pancreas as a zymogen. In other species, elastase 2A has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. Clinical literature that describes human elastase 1 activity in the pancreas is actually referring to elastase 2A.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000142615 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000058579 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Kawashima I, Tani T, Shimoda K, Takiguchi Y (Jul 1987). "Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas". DNA. 6 (2): 163–72. doi:10.1089/dna.1987.6.163. PMID 3646943.
- ^ Shirasu Y, Yoshida H, Matsuki S, Takemura K, Ikeda N, Shimada Y, Ozawa T, Mikayama T, Iijima H, Ishida A, et al. (Jun 1988). "Molecular cloning and expression in Escherichia coli of a cDNA encoding human pancreatic elastase 2". J Biochem. 102 (6): 1555–63. doi:10.1093/oxfordjournals.jbchem.a122204. PMID 2834346.
- ^ a b "Entrez Gene: ELA2A elastase 2A".
External links
Further reading
- Moulard M, Michon T, Kerfelec B, Chapus C (1990). "Further studies on the human pancreatic binary complexes involving procarboxypeptidase A." FEBS Lett. 261 (1): 179–83. doi:10.1016/0014-5793(90)80665-6. PMID 2307232.
- Fletcher TS, Shen WF, Largman C (1988). "Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA". Biochemistry. 26 (23): 7256–61. doi:10.1021/bi00397a010. PMID 3427074.
- Friess H, Ding J, Kleeff J, et al. (2002). "Identification of disease-specific genes in chronic pancreatitis using DNA array technology". Ann. Surg. 234 (6): 769–78, discussion 778–9. doi:10.1097/00000658-200112000-00008. PMC 1422136. PMID 11729383.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Lausen J, Liu S, Fliegauf M, et al. (2006). "ELA2 is regulated by hematopoietic transcription factors, but not repressed by AML1-ETO". Oncogene. 25 (9): 1349–57. doi:10.1038/sj.onc.1209181. PMID 16247445.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
