CYB5R2

Protein-coding gene in the species Homo sapiens
CYB5R2
Identifiers
AliasesCYB5R2, B5R.2, cytochrome b5 reductase 2
External IDsOMIM: 608342; MGI: 2444415; HomoloGene: 6182; GeneCards: CYB5R2; OMA:CYB5R2 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for CYB5R2
Genomic location for CYB5R2
Band11p15.4Start7,665,100 bp[1]
End7,677,222 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for CYB5R2
Genomic location for CYB5R2
Band7|7 E3Start107,347,662 bp[2]
End107,357,239 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left testis

  • right testis

  • tibial nerve

  • sperm

  • sural nerve

  • skin of abdomen

  • skin of leg

  • olfactory zone of nasal mucosa

  • minor salivary glands

  • C1 segment
Top expressed in
  • zygote

  • spermatid

  • lens

  • sciatic nerve

  • secondary oocyte

  • morula

  • embryo

  • muscle of thigh

  • spermatocyte

  • seminiferous tubule
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • oxidoreductase activity
  • protein binding
  • cytochrome-b5 reductase activity, acting on NAD(P)H
  • FAD binding
Cellular component
  • nucleus
  • membrane
  • endoplasmic reticulum membrane
  • mitochondrion
Biological process
  • steroid metabolic process
  • sterol biosynthetic process
  • steroid biosynthetic process
  • lipid metabolism
  • bicarbonate transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51700

320635

Ensembl

ENSG00000166394

ENSMUSG00000048065

UniProt

Q6BCY4

Q3KNK3

RefSeq (mRNA)

NM_001001336
NM_001302826
NM_001302827
NM_016229

NM_001205227
NM_177216

RefSeq (protein)

NP_001289755
NP_001289756
NP_057313

NP_001192156
NP_796190

Location (UCSC)Chr 11: 7.67 – 7.68 MbChr 7: 107.35 – 107.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cytochrome b5 reductase 2 is an enzyme that in humans is encoded by the CYB5R2 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166394 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048065 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: cytochrome b5 reductase 2".
  6. ^ Zhu H, Qiu H, Yoon HW, Huang S, Bunn HF (December 1999). "Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells". Proc. Natl. Acad. Sci. U.S.A. 96 (26): 14742–7. Bibcode:1999PNAS...9614742Z. doi:10.1073/pnas.96.26.14742. PMC 24718. PMID 10611283.

External links

Further reading

  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Heard-Costa NL, Zillikens MC, Monda KL, et al. (2009). Dermitzakis ET (ed.). "NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium". PLOS Genet. 5 (6): e1000539. doi:10.1371/journal.pgen.1000539. PMC 2695005. PMID 19557197.
  • Zhu H, Qiu H, Yoon HW, et al. (1999). "Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells". Proc. Natl. Acad. Sci. U.S.A. 96 (26): 14742–7. Bibcode:1999PNAS...9614742Z. doi:10.1073/pnas.96.26.14742. PMC 24718. PMID 10611283.
  • Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Baker MA, Krutskikh A, Curry BJ, et al. (2005). "Identification of cytochrome-b5 reductase as the enzyme responsible for NADH-dependent lucigenin chemiluminescence in human spermatozoa". Biol. Reprod. 73 (2): 334–42. doi:10.1095/biolreprod.104.037960. PMID 15858218.
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.


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