DBN1

Protein-coding gene in the species Homo sapiens

DBN1

Identifiers

Aliases

DBN1, D0S117E, drebrin 1

External IDs

OMIM: 126660; MGI: 1931838; HomoloGene: 3236; GeneCards: DBN1; OMA:DBN1 - orthologs

Gene location (Human)

Chr.	Chromosome 5 (human)^[1]

Band	5q35.3	Start	177,456,608 bp^[1]
Band	5q35.3	End	177,474,401 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 13 (mouse)^[2]

Band	13 B1\|13 30.06 cM	Start	55,621,242 bp^[2]
Band	13 B1\|13 30.06 cM	End	55,635,924 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

ganglionic eminence

sural nerve

stromal cell of endometrium

ventricular zone

gastric mucosa

ascending aorta

left uterine tube

Descending thoracic aorta

nucleus accumbens

body of uterus

Top expressed in

maxillary prominence

mandibular prominence

ventricular zone

ganglionic eminence

dentate gyrus of hippocampal formation granule cell

superior frontal gyrus

olfactory tubercle

subiculum

neural tube

lateral septal nucleus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	profilin binding protein binding actin binding cadherin binding
Cellular component	cell projection membrane cell-cell junction intracellular anatomical structure cell junction dendrite cell cortex gap junction actomyosin cytoplasm growth cone plasma membrane actin cytoskeleton cytoskeleton postsynaptic density cortical cytoskeleton postsynaptic membrane glutamatergic synapse postsynaptic cytosol
Biological process	cell differentiation cell communication by electrical coupling regulation of dendrite development nervous system development generation of neurons multicellular organism development neural precursor cell proliferation regulation of neuronal synaptic plasticity maintenance of protein location in cell cell communication by chemical coupling actin filament organization positive regulation of synaptic plasticity cytoplasmic sequestering of protein positive regulation of dendritic spine morphogenesis positive regulation of receptor localization to synapse
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


1627


56320

Ensembl


ENSG00000113758


ENSMUSG00000034675

UniProt


Q16643


Q9QXS6

RefSeq (mRNA)

NM_004395 NM_080881 NM_001363541 NM_001364151 NM_001364152
NM_001393630 NM_001393631


NM_001177371 NM_001177372 NM_019813

RefSeq (protein)


NP_004386 NP_543157 NP_001350470 NP_001351080 NP_001351081


NP_001170842 NP_001170843 NP_062787

Location (UCSC)

Chr 5: 177.46 – 177.47 Mb

Chr 13: 55.62 – 55.64 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Drebrin is a protein that in humans is encoded by the DBN1 gene.^[5]^[6]

The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000113758 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034675 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Toda M, Shirao T, Minoshima S, Shimizu N, Toya S, Uyemura K (Nov 1993). "Molecular cloning of cDNA encoding human drebrin E and chromosomal mapping of its gene". Biochem Biophys Res Commun. 196 (1): 468–72. doi:10.1006/bbrc.1993.2273. PMID 8216329.
^ ^a ^b "Entrez Gene: DBN1 drebrin 1".

Shirao T (1995). "The roles of microfilament-associated proteins, drebrins, in brain morphogenesis: a review". J. Biochem. 117 (2): 231–6. doi:10.1093/jb/117.2.231. PMID 7608104.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Harigaya Y, Shoji M, Shirao T, Hirai S (1996). "Disappearance of actin-binding protein, drebrin, from hippocampal synapses in Alzheimer's disease". J. Neurosci. Res. 43 (1): 87–92. doi:10.1002/jnr.490430111. PMID 8838578. S2CID 40336358.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Mammoto A, Sasaki T, Asakura T, et al. (1998). "Interactions of drebrin and gephyrin with profilin". Biochem. Biophys. Res. Commun. 243 (1): 86–9. doi:10.1006/bbrc.1997.8068. PMID 9473484.
Hayashi K, Ishikawa R, Kawai-Hirai R, et al. (2000). "Domain analysis of the actin-binding and actin-remodeling activities of drebrin". Exp. Cell Res. 253 (2): 673–80. doi:10.1006/excr.1999.4663. PMID 10585290.
Peitsch WK, Grund C, Kuhn C, et al. (2000). "Drebrin is a widespread actin-associating protein enriched at junctional plaques, defining a specific microfilament anchorage system in polar epithelial cells". Eur. J. Cell Biol. 78 (11): 767–78. doi:10.1016/s0171-9335(99)80027-2. PMID 10604653.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Kobayashi S, Shirao T, Sasaki T (2001). "Drebrin expression is increased in spinal motoneurons of rats after axotomy". Neurosci. Lett. 311 (3): 165–8. doi:10.1016/S0304-3940(01)02155-3. PMID 11578820. S2CID 15935730.
Shim KS, Lubec G (2002). "Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome". Neurosci. Lett. 324 (3): 209–12. doi:10.1016/S0304-3940(02)00210-0. PMID 12009525. S2CID 20834151.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Shiraishi Y, Mizutani A, Mikoshiba K, Furuichi T (2003). "Coincidence in dendritic clustering and synaptic targeting of homer proteins and NMDA receptor complex proteins NR2B and PSD95 during development of cultured hippocampal neurons". Mol. Cell. Neurosci. 22 (2): 188–201. doi:10.1016/S1044-7431(03)00037-X. PMID 12676529. S2CID 38323844.
Peitsch WK, Hofmann I, Endlich N, et al. (2003). "Cell biological and biochemical characterization of drebrin complexes in mesangial cells and podocytes of renal glomeruli". J. Am. Soc. Nephrol. 14 (6): 1452–63. doi:10.1097/01.ASN.0000069222.63700.DE. PMID 12761245.
Salazar MA, Kwiatkowski AV, Pellegrini L, et al. (2004). "Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton". J. Biol. Chem. 278 (49): 49031–43. doi:10.1074/jbc.M308104200. PMID 14506234.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.