INHBC

Protein-coding gene in the species Homo sapiens
INHBC
Identifiers
AliasesINHBC, IHBC, inhibin beta C, inhibin beta C subunit, inhibin subunit beta C
External IDsOMIM: 601233; MGI: 105932; HomoloGene: 21142; GeneCards: INHBC; OMA:INHBC - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for INHBC
Genomic location for INHBC
Band12q13.3Start57,434,784 bp[1]
End57,452,062 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for INHBC
Genomic location for INHBC
Band10 D3|10 74.5 cMStart127,192,191 bp[2]
End127,206,300 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lobe of liver

  • testicle

  • tibialis anterior muscle

  • pancreatic ductal cell

  • mucosa of ileum

  • deltoid muscle

  • skin of thigh

  • cerebellum

  • cerebellar cortex

  • right hemisphere of cerebellum
Top expressed in
  • liver

  • yolk sac

  • embryo

  • embryo

  • placenta

  • islet of Langerhans
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • growth factor activity
  • transforming growth factor beta receptor binding
  • hormone activity
  • cytokine activity
Cellular component
  • extracellular region
  • extracellular space
Biological process
  • positive regulation of pathway-restricted SMAD protein phosphorylation
  • regulation of MAPK cascade
  • cell development
  • regulation of apoptotic process
  • SMAD protein signal transduction
  • regulation of signaling receptor activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3626

16325

Ensembl

ENSG00000175189

ENSMUSG00000025405

UniProt

P55103

P55104

RefSeq (mRNA)

NM_005538

NM_010565

RefSeq (protein)

NP_005529

NP_034695

Location (UCSC)Chr 12: 57.43 – 57.45 MbChr 10: 127.19 – 127.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Inhibin beta C chain is a protein that in humans is encoded by the INHBC gene.[5][6]

This gene encodes the beta C chain of inhibin, a member of the TGF-beta superfamily. This subunit forms heterodimers with beta A and beta B subunits. Inhibins and activins, also members of the TGF-beta superfamily, are hormones with opposing actions and are involved in hypothalamic, pituitary, and gonadal hormone secretion, as well as growth and differentiation of various cell types.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000175189 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025405 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ H tten G, Neidhardt H, Schneider C, Pohl J (Feb 1995). "Cloning of a new member of the TGF-beta family: a putative new activin beta C chain". Biochem Biophys Res Commun. 206 (2): 608–13. doi:10.1006/bbrc.1995.1086. PMID 7826378.
  6. ^ a b "Entrez Gene: INHBC inhibin, beta C".

Further reading

  • Bernard DJ, Chapman SC, Woodruff TK (2001). "Mechanisms of inhibin signal transduction". Recent Prog. Horm. Res. 56: 417–50. doi:10.1210/rp.56.1.417. PMID 11237224.
  • Mathews LS, Vale WW (1991). "Expression cloning of an activin receptor, a predicted transmembrane serine kinase". Cell. 65 (6): 973–82. doi:10.1016/0092-8674(91)90549-E. PMID 1646080. S2CID 36407277.
  • Schmitt J, Hötten G, Jenkins NA, et al. (1997). "Structure, chromosomal localization, and expression analysis of the mouse inhibin/activin beta C (Inhbc) gene". Genomics. 32 (3): 358–66. doi:10.1006/geno.1996.0130. PMID 8838799.
  • Thomas TZ, Chapman SM, Hong W, et al. (1998). "Inhibins, activins, and follistatins: expression of mRNAs and cellular localization in tissues from men with benign prostatic hyperplasia". Prostate. 34 (1): 34–43. doi:10.1002/(SICI)1097-0045(19980101)34:1<34::AID-PROS5>3.0.CO;2-K. PMID 9428386. S2CID 45515214.
  • Mellor SL, Cranfield M, Ries R, et al. (2001). "Localization of activin beta(A)-, beta(B)-, and beta(C)-subunits in humanprostate and evidence for formation of new activin heterodimers of beta(C)-subunit". J. Clin. Endocrinol. Metab. 85 (12): 4851–8. doi:10.1210/jcem.85.12.7052. PMID 11134153.
  • Casagrandi D, Bearfield C, Geary J, et al. (2003). "Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the placental tissue of patients with pre-eclampsia". Mol. Hum. Reprod. 9 (4): 199–203. doi:10.1093/molehr/gag029. PMID 12651901.
  • Mellor SL, Ball EM, O'Connor AE, et al. (2003). "Activin betaC-subunit heterodimers provide a new mechanism of regulating activin levels in the prostate". Endocrinology. 144 (10): 4410–9. doi:10.1210/en.2003-0225. PMID 12960042.
  • Ushiro Y, Hashimoto O, Seki M, et al. (2007). "Analysis of the function of activin betaC subunit using recombinant protein". J. Reprod. Dev. 52 (4): 487–95. doi:10.1262/jrd.17110. PMID 16627954.


  • v
  • t
  • e
TGFβ receptor superfamily modulators
Type I
ALK1 (ACVRL1)
  • Kinase inhibitors: K-02288
  • ML-347 (LDN-193719, VU0469381)
  • Other inhibitors: Disitertide
ALK2 (ACVR1A)
  • Kinase inhibitors: DMH-1
  • DMH-2
  • Dorsomorphin (BML-275)
  • K-02288
  • ML-347 (LDN-193719, VU0469381)
ALK3 (BMPR1A)
  • Kinase inhibitors: DMH-2
  • Dorsomorphin (BML-275)
  • K-02288
ALK4 (ACVR1B)
  • Kinase inhibitors: A 83-01
  • SB-431542
  • SB-505124
ALK5 (TGFβR1)
ALK6 (BMPR1B)
  • Kinase inhibitors: DMH-2
  • Dorsomorphin (BML-275)
  • K-02288
ALK7 (ACVR1C)
  • Antagonists: Lefty (1, 2)
  • Kinase inhibitors: A 83-01
  • SB-431542
  • SB-505124
Type II
TGFβR2
  • Kinase inhibitors: DMH-2
  • LY-364947
BMPR2
ACVR2A (ACVR2)
ACVR2B
  • Decoy receptors: Ramatercept
AMHR2 (AMHR)
Type III
TGFβR3 (β-glycan)
Unsorted


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