PPIL3

Protein-coding gene in the species Homo sapiens
PPIL3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1XYH, 2OJU, 2OK3

Identifiers
AliasesPPIL3, CYPJ, peptidylprolyl isomerase like 3
External IDsOMIM: 615811; MGI: 1917475; HomoloGene: 41717; GeneCards: PPIL3; OMA:PPIL3 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for PPIL3
Genomic location for PPIL3
Band2q33.1Start200,870,907 bp[1]
End200,889,303 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for PPIL3
Genomic location for PPIL3
Band1|1 C1.3Start58,470,153 bp[2]
End58,484,645 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of ileum

  • pancreatic epithelial cell

  • ganglionic eminence

  • myocardium of left ventricle

  • ventricular zone

  • secondary oocyte

  • right uterine tube

  • tibialis anterior muscle

  • germinal epithelium

  • tibia
Top expressed in
  • facial motor nucleus

  • endothelial cell of lymphatic vessel

  • hand

  • primitive streak

  • primary oocyte

  • otolith organ

  • utricle

  • superior cervical ganglion

  • medullary collecting duct

  • condyle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • isomerase activity
  • protein binding
  • peptidyl-prolyl cis-trans isomerase activity
Cellular component
  • catalytic step 2 spliceosome
  • spliceosomal complex
Biological process
  • mRNA splicing, via spliceosome
  • mRNA processing
  • protein folding
  • RNA splicing
  • protein peptidyl-prolyl isomerization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

53938

70225

Ensembl

ENSG00000240344

ENSMUSG00000026035

UniProt

Q9H2H8

Q9D6L8

RefSeq (mRNA)

NM_032472
NM_130906
NM_131916

NM_001285826
NM_001285827
NM_027351
NM_027374

RefSeq (protein)

NP_115861
NP_570981

NP_001272755
NP_001272756
NP_081627
NP_081650

Location (UCSC)Chr 2: 200.87 – 200.89 MbChr 1: 58.47 – 58.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Peptidyl-prolyl cis-trans isomerase-like 3 is an enzyme that in humans is encoded by the PPIL3 gene.[5][6]

Function

This gene encodes a member of the cyclophilin family. Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide bonds in oligopeptides. They have been proposed to act either as catalysts or as molecular chaperones in protein-folding events. Transcript variants derived from alternative splicing and/or alternative polyadenylation exist; some of these variants encode different isoforms.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000240344 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026035 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zhou Z, Ying K, Dai J, Tang R, Wang W, Huang Y, Zhao W, Xie Y, Mao Y (Jul 2001). "Molecular cloning and characterization of a novel peptidylprolyl isomerase (cyclophilin)-like gene (PPIL3) from human fetal brain". Cytogenetics and Cell Genetics. 92 (3–4): 231–6. doi:10.1159/000056909. PMID 11435694. S2CID 713529.
  6. ^ a b "Entrez Gene: PPIL3 peptidylprolyl isomerase (cyclophilin)-like 3".

Further reading

  • Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (Apr 2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
  • Huang LL, Zhao XM, Huang CQ, Yu L, Xia ZX (Mar 2005). "Structure of recombinant human cyclophilin J, a novel member of the cyclophilin family". Acta Crystallographica Section D. 61 (Pt 3): 316–21. doi:10.1107/S0907444904033189. PMID 15735342.
  • Qi ZY, Hui GZ, Li Y, Zhou ZX, Gu SH, Ying K, Xie Y (May 2005). "cDNA microarray in isolation of novel differentially expressed genes related to human glioma and clone of a novel full-length gene". Chinese Medical Journal. 118 (10): 799–805. PMID 15989758.
  • Hu H, Huang CQ, Liu HL, Han Y, Yu L, Bi RC (Feb 2005). "Crystallization and preliminary X-ray crystallographic studies of human cyclophilin J". Acta Crystallographica Section F. 61 (Pt 2): 216–8. doi:10.1107/S1744309105000643. PMC 1952245. PMID 16510998.
  • v
  • t
  • e
  • 1xyh: Crystal Structure of Recombinant Human Cyclophilin J
    1xyh: Crystal Structure of Recombinant Human Cyclophilin J


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