SNX21

Protein-coding gene in the species Homo sapiens
SNX21
Identifiers
AliasesSNX21, C20orf161, PP3993, SNX-L, dJ337O18.4, sorting nexin family member 21, SNXL
External IDsMGI: 1917729; HomoloGene: 43132; GeneCards: SNX21; OMA:SNX21 - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for SNX21
Genomic location for SNX21
Band20q13.12Start45,833,799 bp[1]
End45,843,276 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for SNX21
Genomic location for SNX21
Band2|2 H3Start164,627,743 bp[2]
End164,635,736 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • skin of leg

  • right ovary

  • left ovary

  • skin of abdomen

  • right coronary artery

  • endothelial cell

  • right adrenal cortex

  • gastric mucosa

  • left adrenal cortex

  • left uterine tube
Top expressed in
  • muscle of thigh

  • Rostral migratory stream

  • lip

  • lumbar spinal ganglion

  • superior frontal gyrus

  • primary visual cortex

  • facial motor nucleus

  • right kidney

  • cerebellar cortex

  • neural layer of retina
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • lipid binding
  • phosphatidylinositol binding
  • phosphatidylinositol-4,5-bisphosphate binding
  • phosphatidylinositol-3-phosphate binding
Cellular component
  • membrane
  • cytoplasmic vesicle
  • cytoplasmic vesicle membrane
  • endosome
  • early endosome membrane
Biological process
  • protein transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

90203

101113

Ensembl

ENSG00000124104

ENSMUSG00000050373

UniProt

Q969T3

Q3UR97

RefSeq (mRNA)

NM_001042632
NM_001042633
NM_033421
NM_152897

NM_133924
NM_001399716

RefSeq (protein)

NP_001036097
NP_001036098
NP_219489
NP_690857

NP_598685
NP_001386645

Location (UCSC)Chr 20: 45.83 – 45.84 MbChr 2: 164.63 – 164.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sorting nexin-21 is a protein that in humans is encoded by the SNX21 gene.[5][6][7]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. The specific function of this protein has not been determined. Multiple transcript variants encoding distinct isoforms have been identified for this gene.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124104 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050373 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Worby CA, Dixon JE (Dec 2002). "Sorting out the cellular functions of sorting nexins". Nat Rev Mol Cell Biol. 3 (12): 919–31. doi:10.1038/nrm974. PMID 12461558. S2CID 36361630.
  6. ^ Zeng W, Yuan W, Wang Y, Jiao W, Zhu Y, Huang C, Li D, Li Y, Zhu C, Wu X, Liu M (Dec 2002). "Expression of a novel member of sorting nexin gene family, SNX-L, in human liver development". Biochem Biophys Res Commun. 299 (4): 542–8. doi:10.1016/S0006-291X(02)02695-5. PMID 12459172.
  7. ^ a b "Entrez Gene: SNX21 sorting nexin family member 21".

Further reading

  • Xu Y, Seet LF, Hanson B, Hong W (2002). "The Phox homology (PX) domain, a new player in phosphoinositide signalling". Biochem. J. 360 (Pt 3): 513–30. doi:10.1042/0264-6021:3600513. PMC 1222253. PMID 11736640.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
  • Teasdale RD, Loci D, Houghton F, et al. (2001). "A large family of endosome-localized proteins related to sorting nexin 1". Biochem. J. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC 1222026. PMID 11485546.
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SNX-BAR
SNX-PX
  • SNX3
  • SNX10
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  • SNX12
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  • SNX20
  • SNX21
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  • SNX29
SNX-Other
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