WSB1

Protein-coding gene in the species Homo sapiens
WSB1
Identifiers
AliasesWSB1, SWIP1, WSB-1, WD repeat and SOCS box containing 1
External IDsOMIM: 610091; MGI: 1926139; HomoloGene: 9218; GeneCards: WSB1; OMA:WSB1 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for WSB1
Genomic location for WSB1
Band17q11.1Start27,294,076 bp[1]
End27,315,926 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for WSB1
Genomic location for WSB1
Band11|11 B5Start79,130,198 bp[2]
End79,145,497 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • corpus callosum

  • gastric mucosa

  • lower lobe of lung

  • inferior ganglion of vagus nerve

  • tibial nerve

  • Region I of hippocampus proper

  • tibial arteries

  • canal of the cervix

  • endothelial cell

  • left uterine tube
Top expressed in
  • medullary collecting duct

  • cumulus cell

  • neural tube

  • dorsomedial hypothalamic nucleus

  • pineal gland

  • vas deferens

  • dermis

  • paraventricular nucleus of hypothalamus

  • ventral tegmental area

  • Gonadal ridge
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
  • ubiquitin-protein transferase activity
Cellular component
  • intracellular anatomical structure
  • cytosol
Biological process
  • protein ubiquitination
  • intracellular signal transduction
  • protein polyubiquitination
  • post-translational protein modification
  • biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26118

78889

Ensembl

ENSG00000109046

ENSMUSG00000017677

UniProt

Q9Y6I7

O54927

RefSeq (mRNA)

NM_015626
NM_134264
NM_134265
NM_001348350

NM_001042565
NM_019653

RefSeq (protein)

NP_056441
NP_599027
NP_001335279

NP_001036030
NP_062627

Location (UCSC)Chr 17: 27.29 – 27.32 MbChr 11: 79.13 – 79.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

WD repeat and SOCS box-containing protein 1 is a protein that in humans is encoded by the WSB1 gene.[5][6][7]

This gene encodes a member of the WD-protein subfamily. This protein shares a high sequence identity to mouse and chick proteins. It contains several WD-repeats spanning most of the protein and an SOCS box in the C-terminus. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000109046 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017677 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Vasiliauskas D, Hancock S, Stern CD (Aug 1999). "SWiP-1: novel SOCS box containing WD-protein regulated by signalling centres and by Shh during development". Mech Dev. 82 (1–2): 79–94. doi:10.1016/S0925-4773(99)00014-3. PMID 10354473. S2CID 15357835.
  6. ^ Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (Jun 2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
  7. ^ a b "Entrez Gene: WSB1 WD repeat and SOCS box-containing 1".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Kamura T, Burian D, Yan Q, et al. (2001). "Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase". J. Biol. Chem. 276 (32): 29748–53. doi:10.1074/jbc.M103093200. PMID 11384984.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Dentice M, Bandyopadhyay A, Gereben B, et al. (2005). "The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate". Nat. Cell Biol. 7 (7): 698–705. doi:10.1038/ncb1272. PMC 1761694. PMID 15965468.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Woo JS, Imm JH, Min CK, et al. (2006). "Structural and functional insights into the B30.2/SPRY domain". EMBO J. 25 (6): 1353–63. doi:10.1038/sj.emboj.7600994. PMC 1422157. PMID 16498413.
  • Chen QR, Bilke S, Wei JS, et al. (2006). "Increased WSB1 copy number correlates with its over-expression which associates with increased survival in neuroblastoma". Genes Chromosomes Cancer. 45 (9): 856–62. doi:10.1002/gcc.20349. PMID 16804916. S2CID 3099056.
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