ITGAM |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/3/37/Protein_ITGAM_PDB_1bho.png/250px-Protein_ITGAM_PDB_1bho.png) |
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Structures disponibles |
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PDB | Recherche d'orthologue: PDBe RCSB |
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Identifiants PDB |
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1BHO, 1BHQ, 1IDN, 1IDO, 1JLM, 1M1U, 1MF7, 1N9Z, 1NA5, 2LKE, 2LKJ, 3Q3G, 3QA3, 4M76, 4XW2 |
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Identifiants |
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Aliases | ITGAM |
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IDs externes | OMIM: 120980 MGI: 96607 HomoloGene: 526 GeneCards: ITGAM |
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Position du gène (Homme) |
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![Chromosome 16 humain](//upload.wikimedia.org/wikipedia/commons/thumb/2/2d/Ideogram_human_chromosome_16.svg/300px-Ideogram_human_chromosome_16.svg.png) | Chr. | Chromosome 16 humain[1] |
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| Locus | 16p11.2 | Début | 31,259,967 bp[1] |
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Fin | 31,332,892 bp[1] |
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Position du gène (Souris) |
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![Chromosome 7 (souris)](//upload.wikimedia.org/wikipedia/commons/thumb/e/e4/Ideogram_house_mouse_chromosome_7.svg/260px-Ideogram_house_mouse_chromosome_7.svg.png) | Chr. | Chromosome 7 (souris)[2] |
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| Locus | 7|7 F3 | Début | 127,661,812 bp[2] |
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Fin | 127,717,663 bp[2] |
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Expression génétique |
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Bgee | Humain | Souris (orthologue) |
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Fortement exprimé dans | - monocyte
- granulocyte
- os spongieux
- moelle osseuse
- sang
- cellule de la moelle osseuse
- rate
- appendice iléo-cæcal
- upper lobe of left lung
- Caduque basale
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| Fortement exprimé dans | - granulocyte
- moelle osseuse
- iléon
- Jéjunum
- rate
- dentate gyrus of hippocampal formation granule cell
- hippocampus proper
- œsophage
- striatum of neuraxis
- utérus
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| Plus de données d'expression de référence |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/1/1b/PBB_GE_ITGAM_205786_s_at_fs.png/250px-PBB_GE_ITGAM_205786_s_at_fs.png) | Plus de données d'expression de référence |
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Gene Ontology |
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Fonction moléculaire | - liaison ion métal
- liaison protéique
- protein heterodimerization activity
- heat shock protein binding
- amyloid-beta binding
- complement component C3b binding
- cargo receptor activity
| Composant cellulaire | - exosome
- membrane plasmique
- surface cellulaire
- membrane
- integral component of membrane
- integrin complex
- milieu extracellulaire
- specific granule membrane
- tertiary granule membrane
- external side of plasma membrane
- integrin alphaM-beta2 complex
- plasma membrane raft
- radeau lipidique
| Processus biologique | - ectodermal cell differentiation
- toll-like receptor 4 signaling pathway
- integrin-mediated signaling pathway
- leukocyte migration
- extracellular matrix organization
- adhésion cellulaire
- neutrophil degranulation
- microglial cell activation
- processus du système immunitaire
- endocytose à récepteur
- phagocytosis, engulfment
- cytokine-mediated signaling pathway
- positive regulation of superoxide anion generation
- positive regulation of neutrophil degranulation
- système immunitaire inné
- negative regulation of dopamine metabolic process
- positive regulation of protein targeting to membrane
- amyloid-beta clearance
- cell-cell adhesion via plasma-membrane adhesion molecules
- complement-mediated synapse pruning
- vertebrate eye-specific patterning
- positive regulation of neuron death
- positive regulation of microglial cell activation
- positive regulation of microglial cell mediated cytotoxicity
- cell surface receptor signaling pathway involved in cell-cell signaling
- positive regulation of prostaglandin-E synthase activity
- forebrain development
- apoptotic signaling pathway
- positive regulation of hippocampal neuron apoptotic process
| Sources:Amigo / QuickGO |
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Orthologues |
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Espèces | Homme | Souris |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protéine) | | |
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Localisation (UCSC) | Chr 16: 31.26 – 31.33 Mb | Chr 7: 127.66 – 127.72 Mb |
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Publication PubMed | [3] | [4] |
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Wikidata |
Voir/Editer Humain | Voir/Editer Souris |
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