NET1

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Neuroepitelni ćelijsko transformišući gen 1 protein

Dostupne strukture

3EO2

Identifikatori

Simboli

NET1; ARHGEF8; NET1A

Vanjski ID

OMIM: 606450 MGI: 1927138 HomoloGene: 4283 GeneCards: NET1 Gene

Ontologija gena
Molekularna funkcija	• aktivnost faktora razmene guanil-nukleotida • fosfolipidno vezivanje
Celularna komponenta	• jedro • citozol
Biološki proces	• regulacija ćelijskog rasta • apoptotički proces • prenos signala

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

Entrez

10276

56349

Ensembl

ENSG00000173848

ENSMUSG00000021215

UniProt

Q7Z628

Q9Z206

RefSeq (mRNA)

NM_001047160

NM_001047159

RefSeq (protein)

NP_001040625

NP_001040624

Lokacija (UCSC)

Chr 10:
5.45 - 5.5 Mb

Chr 13:
3.88 - 3.92 Mb

PubMed pretraga

[1]

[2]

Neuroepitelni ćelijsko transformišući gen 1 protein je kod čoveka kodiran NET1 genom.^[1]^[2]

Reference

↑ Chan AM, Takai S, Yamada K, Miki T (Jul 1996). „Isolation of a novel oncogene, NET1, from neuroepithelioma cells by expression cDNA cloning”. Oncogene 12 (6): 1259–66. PMID 8649828.
↑ „Entrez Gene: NET1 neuroepithelial cell transforming gene 1”.

Literatura

Shen X, Li J, Hu PP, et al. (2001). „The activity of guanine exchange factor NET1 is essential for transforming growth factor-beta-mediated stress fiber formation.”. J. Biol. Chem. 276 (18): 15362–8. DOI:10.1074/jbc.M009534200. PMID 11278519.
Dobrosotskaya IY (2001). „Identification of mNET1 as a candidate ligand for the first PDZ domain of MAGI-1.”. Biochem. Biophys. Res. Commun. 283 (4): 969–75. DOI:10.1006/bbrc.2001.4880. PMID 11350080.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). „Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.”. Genome Res. 14 (9): 1711–8. DOI:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Qin H, Carr HS, Wu X, et al. (2005). „Characterization of the biochemical and transforming properties of the neuroepithelial transforming protein 1.”. J. Biol. Chem. 280 (9): 7603–13. DOI:10.1074/jbc.M412141200. PMID 15611121.
Alberts AS, Qin H, Carr HS, Frost JA (2005). „PAK1 negatively regulates the activity of the Rho exchange factor NET1.”. J. Biol. Chem. 280 (13): 12152–61. DOI:10.1074/jbc.M405073200. PMID 15684429.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). „Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.”. Genome Res. 16 (1): 55–65. DOI:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Leyden J, Murray D, Moss A, et al. (2006). „Net1 and Myeov: computationally identified mediators of gastric cancer.”. Br. J. Cancer 94 (8): 1204–12. DOI:10.1038/sj.bjc.6603054. PMC 2361249. PMID 16552434.
García-Mata R, Dubash AD, Sharek L, et al. (2007). „The nuclear RhoA exchange factor Net1 interacts with proteins of the Dlg family, affects their localization, and influences their tumor suppressor activity.”. Mol. Cell. Biol. 27 (24): 8683–97. DOI:10.1128/MCB.00157-07. PMC 2169424. PMID 17938206.