60S ribosomal protein L36a

Protein found in humans

RPL36A

Available structures

PDB

Human UniProt search: PDBe RCSB

List of PDB id codes
4UG0, 4V6X, 5AJ0, 3J7R, 4V5Z, 4UJD, 3J7P, 4D67, 3J92, 4D5Y, 3J7Q, 4UJE, 3J7O, 4UJC

Identifiers

Aliases

RPL36A, L36A, L44L, MIG6, RPL44, ribosomal protein L36a

External IDs

OMIM: 300902; HomoloGene: 776; GeneCards: RPL36A; OMA:RPL36A - orthologs

Gene location (Human)

Chr.	X chromosome (human)^[1]

Band	Xq22.1	Start	101,390,824 bp^[1]
Band	Xq22.1	End	101,396,155 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

ganglionic eminence

epithelium of colon

ventricular zone

left ovary

right ovary

right uterine tube

skin of abdomen

granulocyte

skin of leg

lactiferous gland

n/a

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	structural constituent of ribosome protein binding RNA binding
Cellular component	cytoplasm ribosome intracellular anatomical structure cytosolic large ribosomal subunit cytosol plasma membrane endoplasmic reticulum polysomal ribosome
Biological process	cytoplasmic translation viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay protein biosynthesis rRNA processing
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6173


n/a

Ensembl


ENSG00000241343


n/a

UniProt


P83881


n/a

RefSeq (mRNA)


NM_021029 NM_001199972


n/a

RefSeq (protein)


NP_066357


n/a

Location (UCSC)

Chr X: 101.39 – 101.4 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

60S ribosomal protein L36a is a protein that in humans is encoded by the RPL36A gene.^[3]^[4]

Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence similarity with yeast ribosomal protein L44, belongs to the L44E (L36AE) family of ribosomal proteins. Although this gene has been referred to as ribosomal protein L44 (RPL44), its official name is ribosomal protein L36a (RPL36A). This gene and the human gene officially named ribosomal protein L36a-like (RPL36AL) encode nearly identical proteins; however, they are distinct genes. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[4]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000241343 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dixit VM, Hennessy SW, Grant GA, Rotwein P, Frazier WA (Sep 1986). "Characterization of a cDNA encoding the heparin and collagen binding domains of human thrombospondin". Proc Natl Acad Sci U S A. 83 (15): 5449–53. Bibcode:1986PNAS...83.5449D. doi:10.1073/pnas.83.15.5449. PMC 386304. PMID 3461443.
^ ^a ^b "Entrez Gene: RPL36A ribosomal protein L36a".

Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
Davies MS, Henney A, Ward WH, Craig RK (1987). "Characterisation of an mRNA encoding a human ribosomal protein homologous to the yeast L44 ribosomal protein". Gene. 45 (2): 183–91. doi:10.1016/0378-1119(86)90253-2. PMID 3542712.
Oeltjen JC, Liu X, Lu J, et al. (1995). "Sixty-nine kilobases of contiguous human genomic sequence containing the alpha-galactosidase A and Bruton's tyrosine kinase loci". Mamm. Genome. 6 (5): 334–8. doi:10.1007/BF00364796. PMID 7626884. S2CID 22686077.
Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
Vorechovský I, Vetrie D, Holland J, et al. (1994). "Isolation of cosmid and cDNA clones in the region surrounding the BTK gene at Xq21.3-q22". Genomics. 21 (3): 517–24. doi:10.1006/geno.1994.1310. PMID 7959728.
Cross SH, Charlton JA, Nan X, Bird AP (1994). "Purification of CpG islands using a methylated DNA binding column". Nat. Genet. 6 (3): 236–44. doi:10.1038/ng0394-236. PMID 8012384. S2CID 12847618.
Oeltjen JC, Malley TM, Muzny DM, et al. (1997). "Large-scale comparative sequence analysis of the human and murine Bruton's tyrosine kinase loci reveals conserved regulatory domains". Genome Res. 7 (4): 315–29. doi:10.1101/gr.7.4.315. PMID 9110171.
Gubin AN, Njoroge JM, Bouffard GG, Miller JL (1999). "Gene expression in proliferating human erythroid cells". Genomics. 59 (2): 168–77. doi:10.1006/geno.1999.5855. PMID 10409428.
Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics. 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID 11401437.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Kim JH, You KR, Kim IH, et al. (2004). "Over-expression of the ribosomal protein L36a gene is associated with cellular proliferation in hepatocellular carcinoma". Hepatology. 39 (1): 129–38. doi:10.1002/hep.20017. PMID 14752831. S2CID 36029858.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Protein biosynthesis: translation (bacterial, archaeal, eukaryotic)

Proteins

Initiation factor

Bacterial

Mitochondrial

MTIF1
MTIF2
MTIF3

Archaeal

aIF1
aIF2
aIF5
aIF6

Eukaryotic

eIF1	eIF1 B SUI1 family eIF1A Y
eIF2	α kinase β γ eIF2A eIF2B 1 2 3 4 5 eIF2D
eIF3	A B C D E F G H I J K L M
eIF4	A 1 2 3 E1 2 3 G 1 2 3 B H
eIF5	EIF5 EIF5A 2 5B
eIF6	EIF6

Elongation factor

Bacterial/Mitochondrial	EF-Tu EF-Ts EF-G EF-4 EF-P TSFM GFM1 GFM2
Archaeal/Eukaryotic	a/eEF-1 A1 2 3 B P1 P2 P3 D E G a/eEF-2

Release factor

Class 1
- eRF1
Class 2/RF3
- GSPT1
- GSPT2

Ribosomal Proteins

Cytoplasmic

60S subunit	RPL3 RPL4 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPL10 RPL10A RPL10-like RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL22 RPL23 RPL23A RPL24 RPL26 RPL27 RPL27A RPL28 RPL29 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36A RPL37 RPL37A RPL38 RPL39 RPL40 RPL41 RPLP0 RPLP1 RPLP2 RRP15-like RSL24D1
40S subunit	RPSA RPS2 RPS3 RPS3A RPS4 (RPS4X, RPS4Y1, RPS4Y2) RPS5 RPS6 RPS7 RPS8 RPS9 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS28 RPS29 RPS30 RACK1

Mitochondrial

39S subunit	MRPL1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42
28S subunit	MRPS1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35

Other concepts

Ribosomal RNA / ribosome subunits

Archaea
(70S)

Large (50S):

Small (30S):

Bacteria
(70S)

Large (50S):

Small (30S):

Eukaryotes

Cytoplasmic (80S)	Large (60S): 5S 5.8S 28S Small (40S): 18S
Mitochondrial (55S)	Large (28S): MT-RNR2, 16S MT-tRNA^Val Small (39S): MT-RNR1, 12S
Chloroplast (70S)	Large (50S): 5S 4.5S 23S Small (30S): 16S