Bone morphogenetic protein 10

Protein-coding gene in the species Homo sapiens
BMP10
Identifiers
AliasesBMP10, entrez:27302, bone morphogenetic protein 10
External IDsOMIM: 608748; MGI: 1338820; HomoloGene: 7644; GeneCards: BMP10; OMA:BMP10 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for BMP10
Genomic location for BMP10
Band2p13.3Start68,860,909 bp[1]
End68,871,397 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for BMP10
Genomic location for BMP10
Band6|6 D1Start87,405,976 bp[2]
End87,414,659 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cardiac muscle tissue of right atrium

  • right auricle

  • right lobe of liver

  • tibialis anterior muscle

  • mucosa of ileum

  • left ventricle

  • gastric mucosa

  • placenta

  • gastrocnemius muscle

  • blood
Top expressed in
  • atrium

  • atrioventricular valve

  • primordial ventricle

  • bulbus cordis

  • myocardium of atrium

  • endocardial cushion

  • cardiac muscle tissue of atrium

  • CA3 field

  • perirhinal cortex

  • ventricle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • cytokine activity
  • receptor serine/threonine kinase binding
  • hormone activity
  • telethonin binding
  • protein binding
  • transforming growth factor beta receptor binding
  • growth factor activity
Cellular component
  • cytoplasm
  • extracellular region
  • cell surface
  • Z disc
  • extracellular space
Biological process
  • regulation of apoptotic process
  • pathway-restricted SMAD protein phosphorylation
  • regulation of MAPK cascade
  • heart trabecula formation
  • SMAD protein signal transduction
  • negative regulation of cardiac muscle hypertrophy
  • adult heart development
  • positive regulation of pathway-restricted SMAD protein phosphorylation
  • positive regulation of sarcomere organization
  • positive regulation of cell proliferation involved in heart morphogenesis
  • cardiac muscle cell proliferation
  • positive regulation of cardiac muscle hypertrophy
  • negative regulation of endothelial cell migration
  • positive regulation of transcription, DNA-templated
  • ventricular cardiac muscle tissue morphogenesis
  • multicellular organism development
  • heart development
  • positive regulation of gene expression
  • cell adhesion
  • negative regulation of cell migration
  • positive regulation of cardiac muscle cell proliferation
  • positive regulation of cartilage development
  • negative regulation of cell growth
  • regulation of cardiac muscle hypertrophy in response to stress
  • atrial cardiac muscle tissue morphogenesis
  • regulation of cardiac muscle contraction
  • sarcomere organization
  • ventricular cardiac muscle cell development
  • activin receptor signaling pathway
  • BMP signaling pathway
  • regulation of signaling receptor activity
  • cell development
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

27302

12154

Ensembl

ENSG00000163217

ENSMUSG00000030046

UniProt

O95393

Q9R229

RefSeq (mRNA)

NM_014482

NM_009756

RefSeq (protein)

NP_055297

NP_033886

Location (UCSC)Chr 2: 68.86 – 68.87 MbChr 6: 87.41 – 87.41 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Bone morphogenetic protein 10 (BMP10) is a protein that in humans is encoded by the BMP10 gene.[5][6]

BMP10 is a polypeptide belonging to the TGF-β superfamily of proteins.[6] It is a novel protein that, unlike most other BMP's, is likely to be involved in the trabeculation of the heart. Bone morphogenetic proteins are known for their ability to induce bone and cartilage development. BMP10 is categorized as a BMP since it shares a large sequence homology with other BMP's in the TGF-β superfamily.

Further reading

  • Davila S, Froeling FE, Tan A, et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496. S2CID 11183658.
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
  • Mazerbourg S, Sangkuhl K, Luo CW, et al. (2005). "Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses". J. Biol. Chem. 280 (37): 32122–32. doi:10.1074/jbc.M504629200. PMID 16049014.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Nakano N, Hori H, Abe M, et al. (2007). "Interaction of BMP10 with Tcap may modulate the course of hypertensive cardiac hypertrophy". Am. J. Physiol. Heart Circ. Physiol. 293 (6): H3396–403. doi:10.1152/ajpheart.00311.2007. PMID 17921333. S2CID 45084505.
  • Marroni F, Pfeufer A, Aulchenko YS, et al. (2009). "A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project". Circ Cardiovasc Genet. 2 (4): 322–8. doi:10.1161/CIRCGENETICS.108.833806. PMC 2760953. PMID 20031603.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • David L, Mallet C, Mazerbourg S, et al. (2007). "Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells". Blood. 109 (5): 1953–61. doi:10.1182/blood-2006-07-034124. PMID 17068149.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163217 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030046 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: bone morphogenetic protein 10".
  6. ^ a b Neuhaus H, Rosen V, Thies RS (February 1999). "Heart specific expression of mouse BMP-10 a novel member of the TGF-beta superfamily". Mech. Dev. 80 (2): 181–4. doi:10.1016/S0925-4773(98)00221-4. PMID 10072785. S2CID 15626081.

External links

  • v
  • t
  • e
TGF beta superfamily of ligands
Ligand of ACVR or TGFBR
Ligand of BMPR
TGF beta receptors
(Activin, BMP, family)
TGFBR1:
TGFBR2:
TGFBR3:
Transducers/SMADLigand inhibitors
CoreceptorsOther
  • v
  • t
  • e
TGFβ receptor superfamily modulators
Type I
ALK1 (ACVRL1)
  • Kinase inhibitors: K-02288
  • ML-347 (LDN-193719, VU0469381)
  • Other inhibitors: Disitertide
ALK2 (ACVR1A)
  • Kinase inhibitors: DMH-1
  • DMH-2
  • Dorsomorphin (BML-275)
  • K-02288
  • ML-347 (LDN-193719, VU0469381)
ALK3 (BMPR1A)
  • Kinase inhibitors: DMH-2
  • Dorsomorphin (BML-275)
  • K-02288
ALK4 (ACVR1B)
  • Kinase inhibitors: A 83-01
  • SB-431542
  • SB-505124
ALK5 (TGFβR1)
ALK6 (BMPR1B)
  • Kinase inhibitors: DMH-2
  • Dorsomorphin (BML-275)
  • K-02288
ALK7 (ACVR1C)
  • Antagonists: Lefty (1, 2)
  • Kinase inhibitors: A 83-01
  • SB-431542
  • SB-505124
Type II
TGFβR2
  • Kinase inhibitors: DMH-2
  • LY-364947
BMPR2
ACVR2A (ACVR2)
ACVR2B
  • Decoy receptors: Ramatercept
AMHR2 (AMHR)
Type III
TGFβR3 (β-glycan)
Unsorted


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