Protein-coding gene in the species Homo sapiens
| CACNG3 |
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| Identifiers |
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| Aliases | CACNG3, calcium voltage-gated channel auxiliary subunit gamma 3 |
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| External IDs | OMIM: 606403; MGI: 1859165; HomoloGene: 4767; GeneCards: CACNG3; OMA:CACNG3 - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 16 (human)[1] |
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| | Band | 16p12.1 | Start | 24,256,335 bp[1] |
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| End | 24,362,412 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 7 (mouse)[2] |
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| | Band | 7|7 F2 | Start | 122,269,715 bp[2] |
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| End | 122,368,616 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - Brodmann area 10
- Brodmann area 46
- orbitofrontal cortex
- Region I of hippocampus proper
- dorsolateral prefrontal cortex
- superior frontal gyrus
- gonad
- right frontal lobe
- postcentral gyrus
- cingulate gyrus
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| | Top expressed in | - superior frontal gyrus
- primary visual cortex
- prefrontal cortex
- dentate gyrus of hippocampal formation granule cell
- piriform cortex
- primary motor cortex
- olfactory tubercle
- cingulate gyrus
- neural layer of retina
- lumbar subsegment of spinal cord
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| | More reference expression data |
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| BioGPS |  | | More reference expression data |
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| Gene ontology |
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| Molecular function | - voltage-gated calcium channel activity
- voltage-gated ion channel activity
- channel regulator activity
- calcium channel activity
- PDZ domain binding
- ionotropic glutamate receptor binding
| | Cellular component | - voltage-gated calcium channel complex
- integral component of membrane
- endocytic vesicle membrane
- plasma membrane
- AMPA glutamate receptor complex
- membrane
- somatodendritic compartment
- dendrite
- excitatory synapse
- postsynaptic density membrane
- Schaffer collateral - CA1 synapse
- glutamatergic synapse
- integral component of postsynaptic density membrane
| | Biological process | - transmission of nerve impulse
- regulation of ion transmembrane transport
- ion transport
- calcium ion transmembrane transport
- calcium ion transport
- regulation of AMPA receptor activity
- protein targeting
- protein localization
- positive regulation of AMPA receptor activity
- neurotransmitter receptor localization to postsynaptic specialization membrane
- positive regulation of synaptic transmission, glutamatergic
- neurotransmitter receptor transport, postsynaptic endosome to lysosome
- postsynaptic neurotransmitter receptor diffusion trapping
- neurotransmitter receptor internalization
- cardiac conduction
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 16: 24.26 – 24.36 Mb | Chr 7: 122.27 – 122.37 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Voltage-dependent calcium channel gamma-3 subunit is a protein that in humans is encoded by the CACNG3 gene.[5][6][7]
L-type calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of several gamma subunit proteins. It is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state. This protein is similar to the mouse stargazin protein, mutations in which have been associated with absence seizures, also known as petit-mal or spike-wave seizures. This gene is a member of the neuronal calcium channel gamma subunit gene subfamily of the PMP-22/EMP/MP20 family. This gene is a candidate gene for a familial infantile convulsive disorder with paroxysmal choreoathetosis.[7]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000006116 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000066189 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Black JL 3rd, Lennon VA (May 1999). "Identification and cloning of putative human neuronal voltage-gated calcium channel gamma-2 and gamma-3 subunits: neurologic implications". Mayo Clin Proc. 74 (4): 357–61. doi:10.4065/74.4.357. PMID 10221464.
- ^ Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (Nov 1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
- ^ a b "Entrez Gene: CACNG3 calcium channel, voltage-dependent, gamma subunit 3".
Further reading
- Powers PA, Liu S, Hogan K, Gregg RG (1993). "Molecular characterization of the gene encoding the gamma subunit of the human skeletal muscle 1,4-dihydropyridine-sensitive Ca2+ channel (CACNLG), cDNA sequence, gene structure, and chromosomal location". J. Biol. Chem. 268 (13): 9275–9. doi:10.1016/S0021-9258(18)98346-8. PMID 8387489.
- Burgess DL, Davis CF, Gefrides LA, Noebels JL (2000). "Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication". Genome Res. 9 (12): 1204–13. doi:10.1101/gr.9.12.1204. PMC 311002. PMID 10613843.
- Burgess DL, Gefrides LA, Foreman PJ, Noebels JL (2001). "A cluster of three novel Ca2+ channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family". Genomics. 71 (3): 339–50. doi:10.1006/geno.2000.6440. PMID 11170751.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Moss FJ, Dolphin AC, Clare JJ (2004). "Human neuronal stargazin-like proteins, gamma2, gamma3 and gamma4; an investigation of their specific localization in human brain and their influence on CaV2.1 voltage-dependent calcium channels expressed in Xenopus oocytes". BMC Neuroscience. 4: 23. doi:10.1186/1471-2202-4-23. PMC 270087. PMID 14505496.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Everett KV, Chioza B, Aicardi J, et al. (2007). "Linkage and association analysis of CACNG3 in childhood absence epilepsy". Eur. J. Hum. Genet. 15 (4): 463–72. doi:10.1038/sj.ejhg.5201783. PMC 2556708. PMID 17264864.
External links
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