Cyclic nucleotide-gated channel alpha 2

Protein-coding gene in humans
CNGA2
Identifiers
AliasesCNGA2, CNCA, CNCA1, CNG2, OCNC1, OCNCALPHA, OCNCa, Cyclic nucleotide-gated channel alpha 2, cyclic nucleotide gated channel alpha 2, cyclic nucleotide gated channel subunit alpha 2
External IDsOMIM: 300338; MGI: 108040; HomoloGene: 32022; GeneCards: CNGA2; OMA:CNGA2 - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for CNGA2
Genomic location for CNGA2
BandXq28Start151,734,746 bp[1]
End151,745,564 bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for CNGA2
Genomic location for CNGA2
BandX|X A7.3Start71,035,455 bp[2]
End71,053,824 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • left testis
Top expressed in
  • olfactory epithelium

  • urethra

  • embryo

  • secondary oocyte

  • zygote

  • primary oocyte

  • entorhinal cortex

  • central gray substance of midbrain

  • superior frontal gyrus

  • thymus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • nucleotide binding
  • cAMP binding
  • calmodulin binding
  • ion channel activity
  • voltage-gated potassium channel activity
  • intracellular cAMP-activated cation channel activity
  • intracellular cGMP-activated cation channel activity
  • cGMP binding
Cellular component
  • integral component of membrane
  • membrane
  • Golgi membrane
  • ciliary membrane
  • Golgi-associated vesicle membrane
  • integral component of plasma membrane
Biological process
  • response to stimulus
  • regulation of membrane potential
  • ion transport
  • sensory perception of smell
  • ion transmembrane transport
  • transmembrane transport
  • potassium ion transmembrane transport
  • cation transmembrane transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1260

12789

Ensembl

ENSG00000183862

ENSMUSG00000005864

UniProt

Q16280

Q62398

RefSeq (mRNA)

NM_005140

NM_007724

RefSeq (protein)

NP_005131

NP_031750

Location (UCSC)Chr X: 151.73 – 151.75 MbChr X: 71.04 – 71.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cyclic nucleotide gated channel alpha 2, also known as CNGA2, is a human gene encoding an ion channel protein.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183862 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005864 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: CNGA2 cyclic nucleotide gated channel alpha 2".

Further reading

  • Trudeau MC, Zagotta WN (2003). "Calcium/calmodulin modulation of olfactory and rod cyclic nucleotide-gated ion channels". J. Biol. Chem. 278 (21): 18705–8. doi:10.1074/jbc.R300001200. PMID 12626507.
  • Hofmann F, Biel M, Kaupp UB (2006). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacol. Rev. 57 (4): 455–62. doi:10.1124/pr.57.4.8. PMID 16382102. S2CID 45853869.
  • Distler M, Biel M, Flockerzi V, Hofmann F (1995). "Expression of cyclic nucleotide-gated cation channels in non-sensory tissues and cells". Neuropharmacology. 33 (11): 1275–82. doi:10.1016/0028-3908(94)90027-2. PMID 7532814. S2CID 35784152.
  • Finn JT, Krautwurst D, Schroeder JE, et al. (1998). "Functional co-assembly among subunits of cyclic-nucleotide-activated, nonselective cation channels, and across species from nematode to human". Biophys. J. 74 (3): 1333–45. Bibcode:1998BpJ....74.1333F. doi:10.1016/S0006-3495(98)77846-4. PMC 1299480. PMID 9512030.
  • Sautter A, Zong X, Hofmann F, Biel M (1998). "An isoform of the rod photoreceptor cyclic nucleotide-gated channel beta subunit expressed in olfactory neurons". Proc. Natl. Acad. Sci. U.S.A. 95 (8): 4696–701. Bibcode:1998PNAS...95.4696S. doi:10.1073/pnas.95.8.4696. PMC 22553. PMID 9539801.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Yoo D, Flagg TP, Olsen O, et al. (2004). "Assembly and trafficking of a multiprotein ROMK (Kir 1.1) channel complex by PDZ interactions". J. Biol. Chem. 279 (8): 6863–73. doi:10.1074/jbc.M311599200. PMID 14604981.
  • Cheng KT, Chan FL, Huang Y, et al. (2004). "Expression of olfactory-type cyclic nucleotide-gated channel (CNGA2) in vascular tissues". Histochem. Cell Biol. 120 (6): 475–81. doi:10.1007/s00418-003-0596-2. PMID 14618336. S2CID 9726100.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Qu W, Moorhouse AJ, Chandra M, et al. (2006). "A single P-loop glutamate point mutation to either lysine or arginine switches the cation-anion selectivity of the CNGA2 channel". J. Gen. Physiol. 127 (4): 375–89. doi:10.1085/jgp.200509378. PMC 2151509. PMID 16533895.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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Ligand-gated
Voltage-gated
Constitutively active
Proton-gated
Voltage-gated
Calcium-activated
Inward-rectifier
Tandem pore domain
Voltage-gated
Miscellaneous
Cl−: Chloride channel
H+: Proton channel
M+: CNG cation channel
M+: TRP cation channel
H2O (+ solutes): Porin
Cytoplasm: Gap junction
By gating mechanism
Ion channel class
see also disorders


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