| # | Date | Film | Gross (USD) | Openings in the top ten |
| 1 | January 3, 2010 | Avatar | $4,238,014 | Sherlock Holmes (#2), All About Steve (#6) |
| 2 | January 10, 2010 | $2,779,199 | Law Abiding Citizen (#5), Zombieland (#6), Labor Pains (#8) |
| 3 | January 17, 2010 | $2,187,381 | Tooth Fairy (#2), Did You Hear About the Morgans? (#5), Fame (#10) |
| 4 | January 24, 2010 | $1,663,426 | Up in the Air (#4), The Fourth Kind (#5), Invictus (#6) |
| 5 | January 31, 2010 | $1,563,033 | The Book of Eli (#3), It's Complicated (#4), Astro Boy (#9) |
| 6 | February 7, 2010 | $1,602,102 | When in Rome (#8) |
| 7 | February 14, 2010 | The Wolfman | $3,506,874 | Percy Jackson & the Olympians: The Lightning Thief (#2), Valentine's Day (#3), The Hurt Locker (#8) |
| 8 | February 21, 2010 | $2,011,764 | The Lovely Bones (#3), Daybreakers (#6) |
| 9 | February 28, 2010 | $1,124,363 | Edge of Darkness (#2), Messengers 2: The Scarecrow (#7), Love Happens (#8), Nine (#10) |
| 10 | March 7, 2010 | Alice in Wonderland | $7,620,403 | Precious (#8) |
| 11 | March 14, 2010 | $5,921,282 | Shutter Island (#2), Extraordinary Measures (#8) |
| 12 | March 21, 2010 | $3,083,139 | The Blind Side (#2), Legion (#4), The Spy Next Door (#5) |
| 13 | March 28, 2010 | How to Train Your Dragon | $2,791,749 | The Bounty Hunter (#3), Remember Me (#6) |
| 14 | April 4, 2010 | $2,253,847 | The Perfect Game (#3), Nanny McPhee and the Big Bang (#6), Dear John (#8), Outlander (#9) |
| 15 | April 11, 2010 | $1,766,037 | Date Night (#2), Hachiko: A Dog's Story (#4) |
| 16 | April 18, 2010 | Clash of the Titans | $7,177,135 | The Echo (#8), The Last Song (#10) |
| 17 | April 25, 2010 | $3,630,198 | The Back-Up Plan (#2), Cop Out (#4), Green Zone (#5) |
| 18 | May 2, 2010 | Iron Man 2 | $7,760,229 | The Crazies (#5), The Road (#10) |
| 19 | May 9, 2010 | $2,726,874 | She's Out of My League (#4) |
| 20 | May 16, 2010 | Robin Hood | $2,961,347 | A Nightmare on Elm Street (#3) |
| 21 | May 23, 2010 | $1,931,951 | Letters to Juliet (#5), To Paris with Love (#6), Oceans (#9), The Losers (#10) |
| 22 | May 30, 2010 | Prince of Persia: The Sands of Time | $4,365,549 | Marmaduke (#2), Abel (#6) |
| 23 | June 6, 2010 | $2,703,969 | Sex and the City 2 (#2), Furry Vengeance (#4), Frozen (#10) |
| 24 | June 13, 2010 | $1,154,666 | The A-Team (#2), Brothers (#8) |
| 25 | June 20, 2010 | Toy Story 3 | $15,088,275 | Killers (#3), Kick-Ass (#7) |
| 26 | June 27, 2010 | $9,589,449 | The Grudge 3 (#4), Celda 211 (#7) |
| 27 | July 4, 2010 | The Twilight Saga: Eclipse | $6,615,500 | Chloe (#6) |
| 28 | July 11, 2010 | The Karate Kid | $3,528,389 | |
| 29 | July 18, 2010 | Shrek Forever After | $8,825,235 | Knight & Day (#4) |
| 30 | July 25, 2010 | $4,795,959 | Grown Ups (#2), Burning Plains (#8) |
| 31 | August 1, 2010 | Despicable Me | $4,103,380 | The Sorcerer's Apprentice (#2), Inception (#4) |
| 32 | August 8, 2010 | $2,940,145 | Salt (#3), Dorian Gray (#8) |
| 33 | August 15, 2010 | $2,240,029 | Cats & Dogs: The Revenge of Kitty Galore (#2), The Expendables (#4), Solomon Kane (#9), The Girl with the Dragon Tattoo (#10) |
| 34 | August 22, 2010 | $1,523,091 | Predators (#2), The Joneses (#9) |
| 35 | August 29, 2010 | The Last Airbender | $4,248,230 | No Eres Tú, Soy Yo (#2), El Atentado (#8) |
| 36 | September 5, 2010 | $2,621,187 | Vampires Suck (#3), El Infierno (#4), Tinker Bell and the Great Fairy Rescue (#5), The Switch (#6) |
| 37 | September 12, 2010 | $1,591,732 | The Ghost Writer (#9), Beyond a Reasonable Doubt (#10) |
| 38 | September 19, 2010 | Resident Evil: Afterlife | $3,230,020 | Hidalgo (#2), Going the Distance (#6), Brijes 3D (#7) |
| 39 | September 26, 2010 | $1,713,534 | Eat, Pray, Love (#5), Héroes Verdaderos (#8) |
| 40 | October 3, 2010 | $1,271,105 | Wall Street: Money Never Sleeps (#2), Charlie St. Cloud (#7) |
| 41 | October 10, 2010 | Legend of the Guardians: The Owls of Ga'Hoole | $1,723,742 | |
| 42 | October 17, 2010 | $1,274,283 | Life as We Know It (#2), The Last Exorcism (#3), Avatar: Special Edition (#4), Dinner for Schmucks (#10) |
| 43 | October 24, 2010 | Paranormal Activity 2 | $1,844,285 | Biutiful (#3) |
| 44 | October 31, 2010 | $1,567,758 | Sammy's Adventures: The Secret Passage (#2), The Town (#3), Saw 3D (#6), Te Presento a Laura (#7), Open Season 3 (#9) |
| 45 | November 7, 2010 | Due Date | $1,268,404 | RED (#4), Back to the Future: 25th Anniversary (#6), Sin Ella (#9) |
| 46 | November 14, 2010 | $921,418 | Buried (#5), Machete (#7), Jackass 3D (#8) |
| 47 | November 21, 2010 | Harry Potter and the Deathly Hallows – Part 1 | $7,916,490 | |
| 48 | November 28, 2010 | $3,510,682 | Tangled (#2), Devil (#3), Skyline (#4), Cyrus (#10) |
| 49 | December 5, 2010 | The Chronicles of Narnia: The Voyage of the Dawn Treader 3D | $2,478,926 | The American (#7) |
| 50 | December 12, 2010 | $3,411,150 | The Social Network (#4), Nowhere Boy (#8), The Greatest (#10) |
| 51 | December 19, 2010 | Megamind | $2,490,886 | Marcelino Pan y Vino (#7), The Killer Inside Me (#10) |
| 52 | December 26, 2010 | Tron: Legacy | $2,864,508 | Gulliver's Travels (#2) |
| 53 | January 2, 2011 | $2,084,555 | Little Fockers (#2), The Next Three Days (#7) |
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