| # | Date | Film | Gross | Notes |
| 1 | January 3, 2010 | Avatar | $764,134 | |
| 2 | January 10, 2010 | Avatar | $804,602 | |
| 3 | January 17, 2010 | Avatar | $321,233 | |
| 4 | January 24, 2010 | Tooth Fairy | $240,675 | |
| 5 | January 31, 2010 | Tooth Fairy | $238,526 | |
| 6 | February 7, 2010 | Old Dogs | $273,396 | |
| 7 | February 14, 2010 | Percy Jackson & the Olympians: The Lightning Thief | $240,668 | |
| 8 | February 21, 2010 | Old Dogs | $234,797 | |
| 9 | February 28, 2010 | Old Dogs | $220,241 | |
| 10 | March 7, 2010 | Alice in Wonderland | $628,604 | |
| 11 | March 14, 2010 | Alice in Wonderland | $602,006 | |
| 12 | March 21, 2010 | Alice in Wonderland | $493,098 | |
| 13 | March 28, 2010 | Alice in Wonderland | $291,301 | |
| 14 | April 4, 2010 | How to Train Your Dragon | $271,301 | |
| 15 | April 11, 2010 | Date Night | $198,981 | |
| 16 | April 18, 2010 | Clash of the Titans | $536,976 | |
| 17 | April 25, 2010 | Clash of the Titans | $439,711 | |
| 18 | May 2, 2010 | Iron Man 2 | $418,341 | |
| 19 | May 9, 2010 | Iron Man 2 | $236,187 | |
| 20 | May 16, 2010 | A Nightmare on Elm Street | $270,756 | |
| 21 | May 23, 2010 | A Nightmare on Elm Street | $254,536 | |
| 22 | May 30, 2010 | Marmaduke | $201,269 | |
| 23 | June 6, 2010 | Robin Hood | $272,388 | |
| 24 | June 13, 2010 | Robin Hood | $203,329 | |
| 25 | June 20, 2010 | Toy Story 3 | $729,863 | |
| 26 | June 27, 2010 | Toy Story 3 | $749,985 | |
| 27 | July 4, 2010 | The Twilight Saga: Eclipse | $711,187 | |
| 28 | July 11, 2010 | Shrek Forever After | $682,613 | |
| 29 | July 18, 2010 | Shrek Forever After | $741,401 | |
| 30 | July 25, 2010 | Shrek Forever After | $614,024 | |
| 31 | August 1, 2010 | Shrek Forever After | $470,193 | |
| 32 | August 8, 2010 | The Karate Kid | $409,123 | |
| 33 | August 15, 2010 | Despicable Me | $465,730 | |
| 34 | August 22, 2010 | Despicable Me | $407,667 | |
| 35 | August 29, 2010 | The Last Airbender | $420,004 | |
| 36 | September 5, 2010 | The Sorcerer's Apprentice | $465,730 | |
| 37 | September 12, 2010 | Resident Evil: Afterlife | $440,431 | |
| 38 | September 19, 2010 | Resident Evil: Afterlife | $368,845 | |
| 39 | September 26, 2010 | Resident Evil: Afterlife | $199,699 | |
| 40 | October 3, 2010 | Legend of the Guardians: The Owls of Ga'Hoole | $332,234 | |
| 41 | October 10, 2010 | Legend of the Guardians: The Owls of Ga'Hoole | $281,138 | |
| 42 | October 17, 2010 | Legend of the Guardians: The Owls of Ga'Hoole | $194,044 | |
| 43 | October 24, 2010 | La Hora Cero | $174,838 | |
| 44 | October 31, 2010 | Saw 3D | $250,576 | |
| 45 | November 7, 2010 | Paranormal Activity 2 | $197,020 | |
| 46 | November 14, 2010 | Life as We Know It | $179,213 | |
| 47 | November 21, 2010 | Harry Potter and the Deathly Hallows – Part 1 | $940,949 | Harry Potter and the Deathly Hallows – Part 1 had the highest weekend debut of 2010. |
| 48 | November 28, 2010 | Tangled | $687,730 | |
| 49 | December 5, 2010 | Tangled | $718,219 | |
| 50 | December 12, 2010 | Megamind | $455,096 | |
| 51 | December 19, 2010 | Tron: Legacy | $465,499 | |
| 52 | December 26, 2010 | Tron: Legacy | $348,980 | |
| 53 | January 2, 2011 | Tron: Legacy | $225,720 | |
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